FIGURE 2
FROM:
Inferring condition-specific transcription factor function from DNA binding and gene expression data
Rachel Patton McCord, Michael F Berger, Anthony A Philippakis & Martha L Bulyk
doi:10.1038/msb4100140
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Physical and genetic interactions recovered by CRACR analysis for the four TFs with PBM data (yellow nodes). A reduced interaction network, containing only those interactions between the query TF and proteins with expression data for a mutant strain (light blue nodes), is shown. Edge thickness corresponds to the enrichment, measured by the maximum area statistic for a window size of 200 genes of TF targets among genes differentially expressed when the interactor is mutated. Solid edges indicate CRACR enrichment significant to P<0.001. Edge color indicates interaction type: genetic (green) or physical (navy).
