FIGURE 3 

Comparison of synchronization behavior between the all-to-all model and random 2D cell arrangements. (A) 2D cell culture geometries are modeled as random Voronoi tessellations of the square. First and second neighbors of the central cell (in yellow) are indicated in green and red, respectively. (B) Synchronization transition for cell cultures with local coupling. The synchronization parameter R is computed as a function of the coupling strength K for three different geometries: all-to-all coupling (red), nearest-neighbor coupling (blue), and coupling extending to second nearest neighbor (purple). For each coupling strength and geometry, 10 000 cells were simulated. Mean and standard error are represented for five independent cell arrangements (details in Supplementary information, section 4).