FIGURE 3
FROM:
Communication between levels of transcriptional control improves robustness and adaptivity
Alexander M Tsankov, Christopher R Brown, Michael C Yu, Moe Z Win, Pamela A Silver & Jason M Casolari
doi:10.1038/msb4100106
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Network validation. (A) Protein–protein associations from previous studies overlap significantly with DNA-binding relationships predicted by the network. (B, C) Experiments support our network's prediction that Sir2 associates with actively transcribed genes in both (B) normal and (C) alpha-factor growth environments. (D) Esc1, another silencing protein, also associates with actively transcribed genes. See Supplementary Table 4 for a list of the gene sets in each Venn diagram.
