FIGURE 6 

(A) Percent of proteins (N=4741) that are essential (knockout lethal) for the top-ranked proteins (1–20%), according to various measures including degree, context degree, context mutual information, and interactive promiscuity. The highest ranked proteins (top 1%) using context-verified degree contain the highest proportion of lethal nodes, but this measure is surpassed by the mutual-information-based measure when we include the top 2%. All three measures outperform degree as a predictor of lethality, although, as we encompass larger numbers of proteins, the differences are less pronounced. (B) Approximate measure cutoffs for corresponding rank levels.