FIGURE 5
FROM:
Biological context networks: a mosaic view of the interactome
John Rachlin, Dikla Dotan Cohen, Charles Cantor & Simon Kasif
doi:10.1038/msb4100103
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(A) DIP yeast sub-network of all 991 essential proteins. (B) Essential proteins having context degree >1. Node coloring is according to the degree of the protein in the full DIP network: 1–4 neighbors (blue), 5–9 neighbors (green), 10–14 neighbors (yellow), 15+ neighbors (red). Many of the essential proteins aggregate into clusters of essential protein complexes that are typically related to cell-cycle regulation and mRNA processing. As a result of the network's improved specificity, context degree is a better predictor for knockout lethality, although applicable only to annotated nodes.
