FIGURE 1 

The local context networks for Sec13 with respect to two of its current GO biological process annotations—GO:0006888, nuclear pore organization and biogenesis, and GO:0006999, ER to Golgi transport—highlighting Sec13's association with both the nuclear pore complex and the ER. Sec13 is an example of a protein whose interacting partners vary from one process context to another. We characterize such proteins as 'interactively promiscuous.' The shuttling of Sec13 between the nucleus and the cytoplasm is believed to play a cross-functional regulatory role (Enninga et al, 2003).