FIGURE 3 

FROM:

Principles of microRNA regulation of a human cellular signaling network

Qinghua Cui, Zhenbao Yu, Enrico O Purisima & Edwin Wang

doi:10.1038/msb4100089

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Relations between the fractions of positive links and the fractions of miRNA targets in network motifs. Each type of motif was classified into several subgroups based on the number of nodes that are miRNA targets. For example, the three-node network motif may have none of their nodes as an miRNA target (category 0), or may have just one of their nodes as an miRNA target (category 1), or two (category 2) or all three as miRNA targets (category 3). The ratio of positive links to total positive and negative links in each subgroup was plotted as a function of miRNA target numbers per motif. The horizontal lines indicate the ratio of positive links to the total positive and negative links in all of the respective network motifs. The network motif ID numbering system is from Alon's motif dictionary (http://www.weizmann.ac.il/mcb/Uri
Alon/NetworkMotifsSW/mfinder/moti
fDictionary.pdf
).

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