FIGURE 1 

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Residues crucial for maintaining short paths in network communication mediate signaling in proteins

Antonio del Sol, Hirotomo Fujihashi, Dolors Amoros & Ruth Nussinov

doi:10.1038/msb4100063

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(A) Averaged distribution of residue centrality of the seven representative protein structures. The average number of residues for each residue centrality z-score interval is indicated at the top of each bar. The average values of the network characteristic path length and clustering coefficient are L=4.21 and C=0.52, respectively. (B) Averaged distribution of residue centrality of the randomly rewired networks of the seven family representative protein structures. The average values of the network characteristic path length and clustering coefficient are L=2.62 and C=0.04, respectively.

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