FIGURE 1 

An SBGN process diagram (A) and a molecular interaction map (B) of a signaling pathway triggered by ligand binding to EGFR molecules. Both diagrams depict ligand-activated phosphorylation and dimerization of EGFR, followed by a phosphorylation cascade involving membrane-bound and cytoplasmic kinases. Phosphorylated kinases (ERK, Rsk2) can transport to the nucleus, where they may activate transcription via the phosphorylation of nuclear transcription factors (myc and CREB). Panel A depicts this pathway as a process diagram (for symbols, see Kitano et al, 2005; Oda et al, 2005); panel B depicts the same pathway as a molecular interaction map (for symbols, see Kohn, 1999, 2001; Kohn et al, 2005).