2.3 SQUARE SQUARE SQUARE SQUARE SQUARE OVAL SQUARE SQUARE_CLOSEUP_NORTH SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive active active active inactive active active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive active inactive inactive inactive inactive active active inactive inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active active inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active active active inactive inactive active inactive active active inactive inactive active inactive inactive inactive active inactive inactive inactive active active inactive inactive active inactive inactive active inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive active inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive active active active active inactive active active inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive active inactive active active inactive active active active inactive active active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive active active inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive also called Mal also called TRIF also called TRAM or TIRP inducible IKK (IKKi) only in mouse PMID: 9159207 autophosphorylation sites: PKCalpha-> T638, S657 PKCbetaII-> T641, S660 vesicle endosome early endosome late endosome ER phagosome outerSurface PROTEIN p1 outerSurface PROTEIN p4 outerSurface PROTEIN p5 outerSurface PROTEIN p6 PMID: 14579267 transmembrane PROTEIN p7 PMID: 14579267 transmembrane PROTEIN p8 outerSurface PROTEIN p10 outerSurface PROTEIN p11 inside PROTEIN p13 inside PROTEIN p11 2 inside PROTEIN p4 PROTEIN p11 inside PROTEIN p16 inside PROTEIN p17 inside PROTEIN p18 inside PROTEIN p19 inside PROTEIN p20 inside PROTEIN p16 PROTEIN p20 inside PROTEIN p21 outerSurface PROTEIN p11 PROTEIN p21 inside PROTEIN p26 inside PROTEIN p27 inside PROTEIN p15 inside PROTEIN p15 2 inside PROTEIN p28 inside DEGRADED a153_degraded inside PROTEIN p34 inside PROTEIN p31 inside PROTEIN p35 inside PROTEIN p36 inside PROTEIN p36 inside PROTEIN p37 inside PROTEIN p37 inside PROTEIN p38 inside PROTEIN p38 inside PROTEIN p39 inside PROTEIN p39 inside PROTEIN p24 inside PROTEIN p23 inside PROTEIN p25 inside PROTEIN p24 PROTEIN p23 PROTEIN p25 inside PROTEIN p27 PROTEIN p26 PROTEIN p15 2 PROTEIN p24 PROTEIN p23 PROTEIN p25 inside PROTEIN p27 PROTEIN p26 PROTEIN p15 2 PROTEIN p24 PROTEIN p23 PROTEIN p25 inside PROTEIN p27 PROTEIN p26 PROTEIN p15 2 PROTEIN p24 PROTEIN p23 PROTEIN p25 inside PROTEIN p27 PROTEIN p26 PROTEIN p15 2 PROTEIN p24 PROTEIN p23 PROTEIN p25 inside PROTEIN p27 PROTEIN p26 PROTEIN p15 2 PROTEIN p24 PROTEIN p23 PROTEIN p25 inside PROTEIN p40 inside PROTEIN p41 inside PROTEIN p34 2 inside PROTEIN p42 inside PROTEIN p46 inside PROTEIN p53 inside PROTEIN p54 inside PROTEIN p47 inside DEGRADED a454_degraded inside PROTEIN p56 inside PROTEIN p57 inside PROTEIN p58 inside PROTEIN p58 2 inside PROTEIN p58 2 inside SIMPLE_MOLECULE dsRNA inside PROTEIN p59 inside PROTEIN p59 inside PHENOTYPE protein_br_systhesis inside PROTEIN p15 2 PROTEIN p58 2 inside PROTEIN p60 inside PROTEIN p61 inside PROTEIN p63 inside PROTEIN p62 inside PROTEIN p62 inside PROTEIN p63 PROTEIN p62 2 inside PROTEIN p62 inside PROTEIN p65 inside PROTEIN p66 inside PROTEIN p67 PROTEIN p15 2 PROTEIN p56 inside PROTEIN p67 inside PROTEIN p68 inside PROTEIN p70 inside PROTEIN p69 inside PROTEIN p69 inside DEGRADED a523_degraded inside SIMPLE_MOLECULE TLR1/2 ligand inside SIMPLE_MOLECULE TLR2/6 ligand inside SIMPLE_MOLECULE TLR2 ligand inside SIMPLE_MOLECULE TLR10 ligand inside SIMPLE_MOLECULE TLR1/10 ligand inside SIMPLE_MOLECULE TLR2/10 ligand inside SIMPLE_MOLECULE TLR5 ligand inside SIMPLE_MOLECULE TLR4 ligand inside SIMPLE_MOLECULE TLR7 ligand inside SIMPLE_MOLECULE TLR8 ligand inside PROTEIN p75 SIMPLE_MOLECULE GDP inside PROTEIN p74 SIMPLE_MOLECULE GDP inside PROTEIN p74 SIMPLE_MOLECULE GTP inside PROTEIN p75 SIMPLE_MOLECULE GTP outerSurface PROTEIN p2 innerSurface PROTEIN p2 2 SIMPLE_MOLECULE TLR2 ligand innerSurface PROTEIN p2 2 SIMPLE_MOLECULE TLR2 ligand inside PROTEIN p73 PROTEIN p43 inside SIMPLE_MOLECULE PI4,5-P_sub_2 inside SIMPLE_MOLECULE PI3,4,5-P_sub_3 inside PROTEIN p12 inside PROTEIN p20 PROTEIN p16 PROTEIN p12 2 inside PROTEIN p20 PROTEIN p12 2 inside PROTEIN p12 2 innerSurface SIMPLE_MOLECULE TLR4 ligand PROTEIN p4 2 PROTEIN p11 2 innerSurface PROTEIN p78 innerSurface PROTEIN p1 PROTEIN p2 SIMPLE_MOLECULE TLR1/2 ligand innerSurface PROTEIN p6 PROTEIN p2 SIMPLE_MOLECULE TLR2/6 ligand inside PROTEIN p32 inside PROTEIN p76 inside PROTEIN p83 inside PROTEIN p83 inside PROTEIN p84 inside PROTEIN p85 transmembrane PROTEIN p7 2 SIMPLE_MOLECULE TLR7 ligand inside PROTEIN p9 2 SIMPLE_MOLECULE TLR9 ligand inside PROTEIN p8 2 SIMPLE_MOLECULE TLR8 ligand innerSurface PROTEIN p1 PROTEIN p10 SIMPLE_MOLECULE TLR1/10 ligand innerSurface PROTEIN p2 PROTEIN p10 SIMPLE_MOLECULE TLR2/10 ligand innerSurface PROTEIN p10 2 SIMPLE_MOLECULE TLR10 ligand innerSurface PROTEIN p5 2 SIMPLE_MOLECULE TLR5 ligand outerSurface PROTEIN p86 inside SIMPLE_MOLECULE TLR11 ligand innerSurface PROTEIN p86 2 SIMPLE_MOLECULE TLR11 ligand inside SIMPLE_MOLECULE TLR3 ligand inside SIMPLE_MOLECULE GDP PROTEIN p87 inside SIMPLE_MOLECULE GTP PROTEIN p87 inside SIMPLE_MOLECULE CpG DNA inside PROTEIN p87 SIMPLE_MOLECULE GTP PROTEIN p9 2 SIMPLE_MOLECULE TLR9 ligand insi