FIGURE 1 

Coexpression and functional associations on the scale of the whole metabolic network. Mean expression distance is plotted as a function of the metabolic network distance separating the metabolic gene pairs for (A) all metabolic gene pairs; (B) positively coexpressed pairs and (C) negatively coexpressed pairs. (D) Fraction of metabolic gene pairs that share at least one transcription factor binding site in their promoter region as a function of metabolic network distance. (E) Mean chromosome clustering gene pair association score dependency. (F) Mean phylogenetic profile cooccurrence association score dependency.