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A global view of pleiotropy and phenotypically derived gene function in yeast

Aimée Marie Dudley, Daniel Maarten Janse, Amos Tanay, Ron Shamir & George McDonald Church

doi:10.1038/msb4100004

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Figure 1

Comparison of UV-sensitive mutants identified in this study, published results from Birrell et al, and a set of UVS mutants collected from the literature

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Figure 2

Cluster profiles (gray scale) and GO functional category enrichment (blue scale)

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Figure 3

Information obtained from phenotypic profile clustering

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Figure 4

A comparison of the information derived from (A) phenotypic profile data and (B) synthetic lethal data

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Figure 5

Phenotype similarity between members of the same protein complex

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Figure 6

Using phenotype profiles to identify separable functions in pleiotropic genes

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Figure 7

Distribution of the number of phenotypically defined functions (biclusters) assigned to the pleiotropic genes in this data set

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Figure 8

Distribution of pleiotropy in our data and 1000 randomly generated sets.

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