FIGURE 6 

FROM:

A global view of pleiotropy and phenotypically derived gene function in yeast

Aimée Marie Dudley, Daniel Maarten Janse, Amos Tanay, Ron Shamir & George McDonald Church

doi:10.1038/msb4100004

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Figure 6: Using phenotype profiles to identify separable functions in pleiotropic genes

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(A) General principle. For a pleiotropic gene (gene3) with growth defects in five conditions (1–3, 6, and 7), it is possible to partition these phenotypes into two sets of functions (blue and purple) based on the results of biclustering. (B) SNF1 example. SNF1 belongs to two biclusters with the phenotypes (HU=hydroxyurea, Gly=glycerol, Cd=cadmium, Cyh=cycloheximide, Caff=caffeine, Rap=rapamycin) outlined in blue and purple. Subsets of the genes present and GO functional categories enriched in each bicluster are also listed.

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