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LATEST: 2008 impact factor 12.243 from Journal Citation Reports, Thomson 2009
Featured article
Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation
Drosophila wing vein differentiation requires the sustained activity of both EGFR and BMP/DPP signaling pathways. We use genetics and modeling to show that it is mediated by a positive feedback circuit where the two pathways cross-activate each other at the level of ligand production.
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Top 10 downloads
- Predicting and controlling the reactivity of immune cell populations against cancer
- Tissue specificity and the human protein interaction network
- Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins
- Discovering structural cis-regulatory elements by modeling the behaviors of mRNAs
- Systems-level interactions between insulin–EGF networks amplify mitogenic signaling
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Research articles
An atlas of chaperone–protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell
Yunchen Gong, Yoshito Kakihara, Nevan Krogan, Jack Greenblatt, Andrew Emili, Zhaolei Zhang & Walid A Houry
doi:10.1038/msb.2009.26
Published online: 16 June 2009
An integrated network approach identifies the isobutanol response network of Escherichia coli
Mark P Brynildsen & James C Liao
doi:10.1038/msb.2009.34
Published online: 16 June 2009
Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology
Brian Cox, Max Kotlyar, Andreas I Evangelou, Vladimir Ignatchenko, Alex Ignatchenko, Kathie Whiteley, Igor Jurisica, S Lee Adamson, Janet Rossant & Thomas Kislinger
doi:10.1038/msb.2009.37
Published online: 16 June 2009
Translational switch for long-term maintenance of synaptic plasticity
Naveed Aslam, Yoshi Kubota, David Wells & Harel Z Shouval
doi:10.1038/msb.2009.38
Published online: 16 June 2009
Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity
Yuichi Kitagawa, Tomoo Hirano & Shin-ya Kawaguchi
doi:10.1038/msb.2009.39
Published online: 16 June 2009
A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability
Amy K Schmid, David J Reiss, Min Pan, Tie Koide & Nitin S Baliga
doi:10.1038/msb.2009.40
Published online: 16 June 2009
Prevalence of transcription promoters within archaeal operons and coding sequences
Tie Koide, David J Reiss, J Christopher Bare, Wyming Lee Pang, Marc T Facciotti, Amy K Schmid, Min Pan, Bruz Marzolf, Phu T Van, Fang-Yin Lo, Abhishek Pratap, Eric W Deutsch, Amelia Peterson, Dan Martin & Nitin S Baliga
doi:10.1038/msb.2009.42
Published online: 16 June 2009
Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins
Esperanza Fernández, Mark O Collins, Rachel T Uren, Maksym V Kopanitsa, Noboru H Komiyama, Mike D R Croning, Lysimachos Zografos, J Douglas Armstrong, Jyoti S Choudhary & Seth G N Grant
doi:10.1038/msb.2009.27
Published online: 19 May 2009
Engineering key components in a synthetic eukaryotic signal transduction pathway
Mauricio S Antunes, Kevin J Morey, Neera Tewari-Singh, Tessa A Bowen, J Jeff Smith, Colleen T Webb, Homme W Hellinga & June I Medford
doi:10.1038/msb.2009.28
Published online: 19 May 2009
Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters
Gilles Curien, Olivier Bastien, Mylène Robert-Genthon, Athel Cornish-Bowden, María Luz Cárdenas & Renaud Dumas
doi:10.1038/msb.2009.29
Published online: 19 May 2009
Reports
Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation
Shian-Jang Yan, Jeremiah J Zartman, Minjie Zhang, Anthony Scott, Stanislav Y Shvartsman & Willis X Li
doi:10.1038/msb.2009.35
Published online: 16 June 2009
Genome-wide allele- and strand-specific expression profiling
Julien Gagneur, Himanshu Sinha, Fabiana Perocchi, Richard Bourgon, Wolfgang Huber & Lars M Steinmetz
doi:10.1038/msb.2009.31
Published online: 16 June 2009
Backup in gene regulatory networks explains differences between binding and knockout results
Anthony Gitter, Zehava Siegfried, Michael Klutstein, Oriol Fornes, Baldo Oliva, Itamar Simon & Ziv Bar-Joseph
doi:10.1038/msb.2009.33
Published online: 16 June 2009
Robustness and fragility in the yeast high osmolarity glycerol (HOG) signal-transduction pathway
Marcus Krantz, Doryaneh Ahmadpour, Lars-Göran Ottosson, Jonas Warringer, Christian Waltermann, Bodil Nordlander, Edda Klipp, Anders Blomberg, Stefan Hohmann & Hiroaki Kitano
doi:10.1038/msb.2009.36
Published online: 16 June 2009
Engineered single- and multi-cell chemotaxis pathways in E. coli
Shalom D Goldberg, Paige Derr, William F DeGrado & Mark Goulian
doi:10.1038/msb.2009.41
Published online: 16 June 2009
Protein sequestration generates a flexible ultrasensitive response in a genetic network
Nicolas E Buchler & Frederick R Cross
doi:10.1038/msb.2009.30
Published online: 19 May 2009
Editorials
Personal phenotypes to go with personal genomes
Michael Snyder, Sherman Weissman & Mark Gerstein
doi:10.1038/msb.2009.32
Published online: 19 May 2009
Personalizing medicine: a systems biology perspective
Thomas S Deisboeck
doi:10.1038/msb.2009.8
Published online: 17 March 2009
More systems biology from NPG & EMBO
A selection of relevant articles hosted by Nature Publishing Group are listed below. More articles can be found on the Systems biology Subject Area page.
