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LATEST: 2006 impact factor 7.941 from Journal Citation Reports, Thomson 2007
Featured article
Reverse engineering of force integration during mitosis in the Drosophila embryo
We use an optimization algorithm to select mechanical models of mitotic spindles in the Drosophila syncytial embryo that can explain available experimental data. The computational search, somewhat similar to the action of natural selection during biological evolution, allows but six groups of models to emerge out of hundreds of thousands possible models, and these models make novel predictions concerning the principles of spindle design.
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- Accurate prediction of protein–protein interactions from sequence alignments using a Bayesian method
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- A systems-level approach to mapping the telomere length maintenance gene circuitry
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Research articles
Reverse engineering of force integration during mitosis in the Drosophila embryo
Roy Wollman, Gul Civelekoglu-Scholey, Jonathan M Scholey & Alex Mogilner
doi:10.1038/msb.2008.23
Published online: 06 May 2008
Network-based global inference of human disease genes
Xuebing Wu, Rui Jiang, Michael Q Zhang & Shao Li
doi:10.1038/msb.2008.27
Published online: 06 May 2008
Colored extrinsic fluctuations and stochastic gene expression
Vahid Shahrezaei, Julien F Ollivier & Peter S Swain
doi:10.1038/msb.2008.31
Published online: 06 May 2008
Mathematical modeling of pathogenicity of Cryptococcus neoformans
Jacqueline Garcia, John Shea, Fernando Alvarez-Vasquez, Asfia Qureshi, Chiara Luberto, Eberhard O Voit & Maurizio Del Poeta
doi:10.1038/msb.2008.17
Published online: 15 April 2008
Transient heterogeneity in extracellular protease production by Bacillus subtilis
Jan-Willem Veening, Oleg A Igoshin, Robyn T Eijlander, Reindert Nijland, Leendert W Hamoen & Oscar P Kuipers
doi:10.1038/msb.2008.18
Published online: 15 April 2008
A map of human protein interactions derived from co-expression of human mRNAs and their orthologs
Arun K Ramani, Zhihua Li, G Traver Hart, Mark W Carlson, Daniel R Boutz & Edward M Marcotte
doi:10.1038/msb.2008.19
Published online: 15 April 2008
Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression
Sujun Hua, Caleb B Kallen, Ruby Dhar, Maria T Baquero, Christopher E Mason, Beth A Russell, Parantu K Shah, Jiang Liu, Andrey Khramtsov, Maria S Tretiakova, Thomas N Krausz, Olufunmilayo I Olopade, David L Rimm & Kevin P White
doi:10.1038/msb.2008.25
Published online: 15 April 2008
Reports
Recursive construction of perfect DNA molecules from imperfect oligonucleotides
Gregory Linshiz, Tuval Ben Yehezkel, Shai Kaplan, Ilan Gronau, Sivan Ravid, Rivka Adar & Ehud Shapiro
doi:10.1038/msb.2008.26
Published online: 06 May 2008
Recurrent design patterns in the feedback regulation of the mammalian signalling network
Stefan Legewie, Hanspeter Herzel, Hans V Westerhoff & Nils Blüthgen
doi:10.1038/msb.2008.29
Published online: 06 May 2008
Large-scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis
Naoyuki Sugiyama, Hirofumi Nakagami, Keiichi Mochida, Arsalan Daudi, Masaru Tomita, Ken Shirasu & Yasushi Ishihama
doi:10.1038/msb.2008.32
Published online: 06 May 2008
A synthetic Escherichia coli predator–prey ecosystem
Frederick K Balagaddé, Hao Song, Jun Ozaki, Cynthia H Collins, Matthew Barnet, Frances H Arnold, Stephen R Quake & Lingchong You
doi:10.1038/msb.2008.24
Published online: 15 April 2008
Ultrasensitive gene regulation by positive feedback loops in nucleosome modification
Kim Sneppen, Mille A Micheelsen & Ian B Dodd
doi:10.1038/msb.2008.21
Published online: 15 April 2008
News & Views
A theoretical model of mitotic spindle elongation under experimental constraints
Thomas Surrey
doi:10.1038/msb.2008.33
Published online: 06 May 2008
Perspectives
Understanding NF-κB signaling via mathematical modeling
Raymond Cheong, Alexander Hoffmann & Andre Levchenko
doi:10.1038/msb.2008.30
Published online: 06 May 2008
Formulating genome-scale kinetic models in the post-genome era
Neema Jamshidi & Bernhard Ø Palsson
doi:10.1038/msb.2008.8
Published online: 04 March 2008
Reviews
Theoretical and experimental approaches to understand morphogen gradients
Marta Ibañes & Juan Carlos Izpisúa Belmonte
doi:10.1038/msb.2008.14
Published online: 25 March 2008
A comprehensive modular map of molecular interactions in RB/E2F pathway
Laurence Calzone, Amélie Gelay, Andrei Zinovyev, François Radvanyi & Emmanuel Barillot
doi:10.1038/msb.2008.7
Published online: 04 March 2008
Editorials
Synthetic biology: promises and challenges
Luis Serrano
doi:10.1038/msb4100202
Published online: 18 December 2007
More systems biology from NPG & EMBO
A selection of relevant articles hosted by Nature Publishing Group are listed below. More articles can be found on the Systems biology Subject Area page.
