Selection to minimise noise in living systems and its implications for the evolution of gene expression
Ben Lehner
doi:10.1038/msb.2008.11
Published online:
04 March 2008
Subject archive
Simulation and data analysis
2008
The role of disorder in interaction networks: a structural analysis
Philip M Kim, Andrea Sboner, Yu Xia & Mark Gerstein
doi:10.1038/msb.2008.16
Published online:
25 March 2008
Ultrasensitive gene regulation by positive feedback loops in nucleosome modification
Kim Sneppen, Mille A Micheelsen & Ian B Dodd
doi:10.1038/msb.2008.21
Published online:
15 April 2008
Recurrent design patterns in the feedback regulation of the mammalian signalling network
Stefan Legewie, Hanspeter Herzel, Hans V Westerhoff & Nils Blüthgen
doi:10.1038/msb.2008.29
Published online:
06 May 2008
Understanding NF-
B signaling via mathematical modeling
Raymond Cheong, Alexander Hoffmann & Andre Levchenko
doi:10.1038/msb.2008.30
Published online:
06 May 2008
Isoform switching facilitates period control in the Neurospora crassa circadian clock
Ozgur E Akman, James C W Locke, Sanyi Tang, Isabelle Carré, Andrew J Millar & David A Rand
doi:10.1038/msb.2008.5
Published online:
12 February 2008
Synopsis | Full Text | PDF (390K) | Supplementary information
Computer-aided rational design of the phosphotransferase system for enhanced glucose uptake in Escherichia coli
Yousuke Nishio, Yoshihiro Usuda, Kazuhiko Matsui & Hiroyuki Kurata
doi:10.1038/msb4100201
Published online:
15 January 2008
Synopsis | Full Text | PDF (1,965K) | Supplementary information
2007
Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
Sean D Hooper, Stephanie Boué, Roland Krause, Lars J Jensen, Christopher E Mason, Murad Ghanim, Kevin P White, Eileen EM Furlong & Peer Bork
doi:10.1038/msb4100112
Published online:
16 January 2007
Synopsis | Full Text | PDF (552K) | Supplementary information
Chemical combination effects predict connectivity in biological systems
Joseph Lehár, Grant R Zimmermann, Andrew S Krueger, Raymond A Molnar, Jebediah T Ledell, Adrian M Heilbut, Glenn F Short, III, Leanne C Giusti, Garry P Nolan, Omar A Magid, Margaret S Lee, Alexis A Borisy, Brent R Stockwell & Curtis T Keith
doi:10.1038/msb4100116
Published online:
27 February 2007
Synopsis | Full Text | PDF (616K) | Supplementary information
How to infer gene networks from expression profiles
Mukesh Bansal, Vincenzo Belcastro, Alberto Ambesi-Impiombato & Diego di Bernardo
doi:10.1038/msb4100120
Published online:
13 February 2007
Computational analysis of the synergy among multiple interacting genes
Dimitris Anastassiou
doi:10.1038/msb4100124
Published online:
13 February 2007
A systems biology dynamical model of mammalian G1 cell cycle progression
Thomas Haberichter, Britta Mädge, Renee A Christopher, Naohisa Yoshioka, Anjali Dhiman, Robert Miller, Rina Gendelman, Sergej V Aksenov, Iya G Khalil & Steven F Dowdy
doi:10.1038/msb4100126
Published online:
13 February 2007
Functioning and robustness of a bacterial circadian clock
Sébastien Clodong, Ulf Dühring, Luiza Kronk, Annegret Wilde, Ilka Axmann, Hanspeter Herzel & Markus Kollmann
doi:10.1038/msb4100128
Published online:
13 March 2007
Synopsis | Full Text | PDF (564K) | Supplementary information
Dynamical signatures of cellular fluctuations and oscillator stability in peripheral circadian clocks
Jacques Rougemont & Felix Naef
doi:10.1038/msb4100130
Published online:
13 March 2007
Revealing static and dynamic modular architecture of the eukaryotic protein interaction network
Kakajan Komurov & Michael White
doi:10.1038/msb4100149
Published online:
24 April 2007
Synopsis | Full Text | PDF (1,146K) | Supplementary information
The adapter importin-
provides flexible control of nuclear import at the expense of efficiency
Greg Riddick & Ian G Macara
doi:10.1038/msb4100160
Published online:
05 June 2007
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
Robert Schuetz, Lars Kuepfer & Uwe Sauer
doi:10.1038/msb4100162
Published online:
10 July 2007
Synopsis | Full Text | PDF (278K) | Supplementary information
Increased glycolytic flux as an outcome of whole-genome duplication in yeast
Gavin C Conant & Kenneth H Wolfe
doi:10.1038/msb4100170
Published online:
31 July 2007
Synopsis | Full Text | PDF (251K) | Supplementary information
Single-cell zeroth-order protein degradation enhances the robustness of synthetic oscillator
Wilson W Wong, Tony Y Tsai & James C Liao
doi:10.1038/msb4100172
Published online:
31 July 2007
Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses
Marc R Birtwistle, Mariko Hatakeyama, Noriko Yumoto, Babatunde A Ogunnaike, Jan B Hoek & Boris N Kholodenko
doi:10.1038/msb4100188
Published online:
13 November 2007
Synopsis | Full Text | PDF (646K) | Supplementary information
Deriving structure from evolution: metazoan segmentation
Paul François, Vincent Hakim & Eric D Siggia
doi:10.1038/msb4100192
Published online:
18 December 2007
Synopsis | Full Text | PDF (212K) | Supplementary information
2006
Noise resistance in the spindle assembly checkpoint
Andreas Doncic, Eshel Ben-Jacob & Naama Barkai
doi:10.1038/msb4100070
Published online:
16 May 2006
Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data
Anne Kümmel, Sven Panke & Matthias Heinemann
doi:10.1038/msb4100074
Published online:
20 June 2006
Synopsis | Full Text | PDF (182K) | Supplementary information
Noise in transcription negative feedback loops: simulation and experimental analysis
Yann Dublanche, Konstantinos Michalodimitrakis, Nico Kümmerer, Mathilde Foglierini & Luis Serrano
doi:10.1038/msb4100081
Published online:
01 August 2006
Cell lineage transport: a mechanism for molecular gradient formation
Marta Ibañes, Yasuhiko Kawakami, Diego Rasskin-Gutman & Juan Carlos Izpisúa Belmonte
doi:10.1038/msb4100098
Published online:
17 October 2006
Synopsis | Full Text | PDF (514K) | Supplementary information
Imaging single molecules in living cells for systems biology
Yasushi Sako
doi:10.1038/msb4100100
Published online:
17 October 2006
Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades
Nick I Markevich, Mikhail A Tsyganov, Jan B Hoek & Boris N Kholodenko
doi:10.1038/msb4100108
Published online:
14 November 2006
Robustness and modular design of the Drosophila segment polarity network
Wenzhe Ma, Luhua Lai, Qi Ouyang & Chao Tang
doi:10.1038/msb4100111
Published online:
12 December 2006
Synopsis | Full Text | PDF (183K) | Supplementary information
2005
Local signaling with molecular diffusion as a decoder of Ca2+ signals in synaptic plasticity
Honda Naoki, Yuichi Sakumura & Shin Ishii
doi:10.1038/msb4100035
Published online:
13 December 2005
Synopsis | Full Text | PDF (417K) | Supplementary information
