Molecular Biology of Disease
2009
A systems approach to prion disease
Daehee Hwang,
Inyoul Y Lee,
Hyuntae Yoo,
Nils Gehlenborg,
Ji-Hoon Cho,
Brianne Petritis,
David Baxter,
Rose Pitstick,
Rebecca Young,
Doug Spicer,
Nathan D Price,
John G Hohmann,
Stephen J DeArmond,
George A Carlson
&
Leroy E Hood
doi:10.1038/msb.2009.10
Published online:
24 March 2009
Synopsis | Full Text | PDF (5,890K) | Supplementary information
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease
Svati H Shah,
Elizabeth R Hauser,
James R Bain,
Michael J Muehlbauer,
Carol Haynes,
Robert D Stevens,
Brett R Wenner,
Z Elaine Dowdy,
Christopher B Granger,
Geoffrey S Ginsburg,
Christopher B Newgard
&
William E Kraus
doi:10.1038/msb.2009.11
Published online:
07 April 2009
Full Text | PDF (337K) | Supplementary information
Predicting and controlling the reactivity of immune cell populations against cancer
Kfir Oved,
Eran Eden,
Martin Akerman,
Roy Noy,
Ron Wolchinsky,
Orit Izhaki,
Ester Schallmach,
Adva Kubi,
Naama Zabari,
Jacob Schachter,
Uri Alon,
Yael Mandel-Gutfreund,
Michal J Besser
&
Yoram Reiter
doi:10.1038/msb.2009.15
Published online:
28 April 2009
Synopsis | Full Text | PDF (3,394K) | Supplementary information
The impact of cellular networks on disease comorbidity
Juyong Park,
Deok-Sun Lee,
Nicholas A Christakis
&
Albert-László Barabási
doi:10.1038/msb.2009.16
Published online:
07 April 2009
Full Text | PDF (587K) | Supplementary information
Predicting metabolic biomarkers of human inborn errors of metabolism
Tomer Shlomi,
Moran N Cabili
&
Eytan Ruppin
doi:10.1038/msb.2009.22
Published online:
28 April 2009
Full Text | PDF (287K) | Supplementary information
Disease signatures are robust across tissues and experiments
Joel T Dudley,
Robert Tibshirani,
Tarangini Deshpande
&
Atul J Butte
doi:10.1038/msb.2009.66
Published online:
15 September 2009
Full Text | PDF (1,317K) | Supplementary information
Edgetic perturbation models of human inherited disorders
Quan Zhong,
Nicolas Simonis,
Qian-Ru Li,
Benoit Charloteaux,
Fabien Heuze,
Niels Klitgord,
Stanley Tam,
Haiyuan Yu,
Kavitha Venkatesan,
Danny Mou,
Venus Swearingen,
Muhammed A Yildirim,
Han Yan,
Amélie Dricot,
David Szeto,
Chenwei Lin,
Tong Hao,
Changyu Fan,
Stuart Milstein,
Denis Dupuy,
Robert Brasseur,
David E Hill,
Michael E Cusick
&
Marc Vidal
doi:10.1038/msb.2009.80
Published online:
03 November 2009
Synopsis | Full Text | PDF (1,786K) | Supplementary information
2008
A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas
Kartik M Mani,
Celine Lefebvre,
Kai Wang,
Wei Keat Lim,
Katia Basso,
Riccardo Dalla-Favera
&
Andrea Califano
doi:10.1038/msb.2008.2
Published online:
12 February 2008
Full Text | PDF (2,674K) | Supplementary information
Network-based global inference of human disease genes
Xuebing Wu,
Rui Jiang,
Michael Q Zhang
&
Shao Li
doi:10.1038/msb.2008.27
Published online:
06 May 2008
Synopsis | Full Text | PDF (3,282K) | Supplementary information
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Oded Shaham,
Ru Wei,
Thomas J Wang,
Catherine Ricciardi,
Gregory D Lewis,
Ramachandran S Vasan,
Steven A Carr,
Ravi Thadhani,
Robert E Gerszten
&
Vamsi K Mootha
doi:10.1038/msb.2008.50
Published online:
05 August 2008
Synopsis | Full Text | PDF (318K) | Supplementary information
Finding multiple target optimal intervention in disease-related molecular network
Kun Yang,
Hongjun Bai,
Qi Ouyang,
Luhua Lai
&
Chao Tang
doi:10.1038/msb.2008.60
Published online:
04 November 2008
Synopsis | Full Text | PDF (2,598K) | Supplementary information
p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
Ran Brosh,
Reut Shalgi,
Atar Liran,
Gilad Landan,
Katya Korotayev,
Giang Huong Nguyen,
Espen Enerly,
Hilde Johnsen,
Yosef Buganim,
Hilla Solomon,
Ido Goldstein,
Shalom Madar,
Naomi Goldfinger,
Anne-Lise Børresen-Dale,
Doron Ginsberg,
Curtis C Harris,
Yitzhak Pilpel,
Moshe Oren
&
Varda Rotter
doi:10.1038/msb.2008.65
Published online:
25 November 2008
Synopsis | Full Text | PDF (6,255K) | Supplementary information
The liver pharmacological and xenobiotic gene response repertoire
Georges Natsoulis,
Cecelia I Pearson,
Jeremy Gollub,
Barrett P Eynon,
Joe Ferng,
Ramesh Nair,
Radha Idury,
May D Lee,
Mark R Fielden,
Richard J Brennan,
Alan H Roter
&
Kurt Jarnagin
doi:10.1038/msb.2008.9
Published online:
25 March 2008
Synopsis | Full Text | PDF (318K) | Supplementary information
1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death
Ville-Petteri Mäkinen,
Pasi Soininen,
Carol Forsblom,
Maija Parkkonen,
Petri Ingman,
Kimmo Kaski,
Per-Henrik Groop
&
Mika Ala-Korpela
for
the FinnDiane Study Group
doi:10.1038/msb4100205
Published online:
12 February 2008
Synopsis | Full Text | PDF (1,017K) | Supplementary information
2007
Computational analysis of the synergy among multiple interacting genes
Dimitris Anastassiou
doi:10.1038/msb4100124
Published online:
13 February 2007
Full Text | PDF (172K) | Supplementary information
A network biology approach to prostate cancer
Ayla Ergün,
Carolyn A Lawrence,
Michael A Kohanski,
Timothy A Brennan
&
James J Collins
doi:10.1038/msb4100125
Published online:
13 February 2007
Full Text | PDF (162K) | Supplementary information
Hubs in biological interaction networks exhibit low changes in expression in experimental asthma
Xin Lu,
Vipul V Jain,
Patricia W Finn
&
David L Perkins
doi:10.1038/msb4100138
Published online:
17 April 2007
Full Text | PDF (419K) | Supplementary information
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model
François-Pierre J Martin,
Marc-Emmanuel Dumas,
Yulan Wang,
Cristina Legido-Quigley,
Ivan K S Yap,
Huiru Tang,
Séverine Zirah,
Gerard M Murphy,
Olivier Cloarec,
John C Lindon,
Norbert Sprenger,
Laurent B Fay,
Sunil Kochhar,
Peter van Bladeren,
Elaine Holmes
&
Jeremy K Nicholson
doi:10.1038/msb4100153
Published online:
22 May 2007
Synopsis | Full Text | PDF (654K) | Supplementary information
Human disease classification in the postgenomic era: A complex systems approach to human pathobiology
Joseph Loscalzo,
Isaac Kohane
&
Albert-Laszlo Barabasi
doi:10.1038/msb4100163
Published online:
10 July 2007
Full Text | PDF (2,243K)
An integrated approach to prognosis using protein microarrays and nonparametric methods
Tanya Knickerbocker,
Jiunn R Chen,
Ravi Thadhani
&
Gavin MacBeath
doi:10.1038/msb4100167
Published online:
26 June 2007
Full Text | PDF (315K) | Supplementary information
Network-based classification of breast cancer metastasis
Han-Yu Chuang,
Eunjung Lee,
Yu-Tsueng Liu,
Doheon Lee
&
Trey Ideker
doi:10.1038/msb4100180
Published online:
16 October 2007
Full Text | PDF (439K) | Supplementary information
A modular network model of aging
Huiling Xue,
Bo Xian,
Dong Dong,
Kai Xia,
Shanshan Zhu,
Zhongnan Zhang,
Lei Hou,
Qingpeng Zhang,
Yi Zhang
&
Jing-Dong J Han
doi:10.1038/msb4100189
Published online:
04 December 2007
Synopsis | Full Text | PDF (321K) | Supplementary information
Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy
Ido Amit,
Ron Wides
&
Yosef Yarden
doi:10.1038/msb4100195
Published online:
04 December 2007
Full Text | PDF (330K)
A map of human cancer signaling
Qinghua Cui,
Yun Ma,
Maria Jaramillo,
Hamza Bari,
Arif Awan,
Song Yang,
Simo Zhang,
Lixue Liu,
Meng Lu,
Maureen O'Connor-McCourt,
Enrico O Purisima
&
Edwin Wang
doi:10.1038/msb4100200
Published online:
18 December 2007
Synopsis | Full Text | PDF (3,123K) | Supplementary information
2006
Dynamic analysis of optimality in myocardial energy metabolism under normal and ischemic conditions
Ruo-Yu Luo,
Sha Liao,
Guan-Yang Tao,
Yuan-Yuan Li,
Shaoqun Zeng,
Yi-Xue Li
&
Qingming Luo
doi:10.1038/msb4100071
Published online:
06 June 2006
Full Text | PDF (156K) | Supplementary information
Systems biology of SNPs
Neema Jamshidi
&
Bernhard Ø Palsson
doi:10.1038/msb4100077
Published online:
04 July 2006
Full Text | PDF (249K) | Supplementary information