Antipsychotic drugs antagonise human serotonin type 3 (5-HT3) receptor currents in a noncompetitive manner

doi:doi:10.1038/sj.mp.4001567

Molecular Psychiatry (2004) 9, 818. doi:10.1038/sj.mp.4001567

Antipsychotic drugs antagonise human serotonin type 3 (5-HT₃) receptor currents in a noncompetitive manner

G Rammes¹, B Eisensamer^1,2, U Ferrari¹, M Shapa², G Gimpl³, K Gilling⁴, C Parsons⁴, K Riering^1,2, G Hapfelmeier^1,5, B Bondy², W Zieglgänsberger¹, F Holsboer¹ and R Rupprecht^1,2

¹Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2-10, Munich, Germany
²Department of Psychiatry, Ludwig-Maximilians-Universität, Nussbaumstrasse 7, Munich, Germany
³Institute of Biochemistry, Johannes-Gutenberg-Universität, Becherweg 30, Mainz, Germany
⁴Merz Pharmaceuticals, Eckenheimer Landstrasse 104, Frankfurt/Main, Germany
⁵Department of Anaesthesiology, Technische Universität München, Ismaninger Strasse 22, Munich, Germany