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Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands

Molecular Psychiatry volume 6, pages 450–455 (2001)Cite this article

Abstract

A number of studies have strongly suggested a susceptibility locus for bipolar affective disorder on chromosome 12q24. The present study investigates for a shared chromosomal segment among distantly related patients with bipolar affective disorder from the Faroe Islands, using 17 microsatellite markers covering 24 cM in the previously suggested region on chromosome 12q24. D12S342 showed possible allelic association to bipolar affective disorder (P-value using CLUMP below 0.01). Increased sharing among cases of two-marker haplotypes were suggested at D12S1614–D12S342 (P-values using CLUMP below 0.01), and D12S2075–D12S1675 (P-values using CLUMP around 0.001). The region of most interest is around 6 cM and bounded by markers D12S1614 and D12S1675 as suggested by the interesting two-marker haplotypes. This area contains the minimum interesting region between D12S342 and D12S1658 suggested by the previously reported haplotypes in the two Danish families with bipolar affective disorder.

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Acknowledgements

The authors wish to thank senior psychiatrist Aksel Bertelsen, Psychiatric Hospital in Aarhus, for the thorough reading of all reports and medical records, and for performing the diagnostic evaluations according to ICD-10.

This work has been supported by: The Danish Medical Research Council; grant numbers 9601887 and 9902769. The Lundbeck Foundation; grants numbered 39/98 and 59/99. Psykiatrisk Forskningsfond. A grant from Einer Geert-Jorgensen foundation. A grant from Ingeborg and Leo Dannin. Ministry of Education, Culture and Research, The Faroese Government; Research Fund of the Faroese Savings Bank, Torshavn, Faroe Islands; Danish Hospital Foundation for Medical Research, Region of Copenhagen, the Faroe Islands and Greenland. Grants from Simon Fougner Hartmann, EilifTrier-Hansen, and Dagmar Marshall foundations.

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Authors and Affiliations

  1. Department of Biological Psychiatry, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Risskov, DK-8240, Denmark

    B Degn, M D Lundorf & H Ewald

  2. Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Risskov, DK-8240, Denmark

    O Mors & H Ewald

  3. Department of Psychiatry, National Hospital, Torshavn, Faroe Islands, Denmark

    A Wang & M Vang

  4. Copenhagen University Hospital, Denmark

    A Wang

  5. Department of Clinical Biochemistry and Genetics, Odense University Hospital, Odense, DK-5000, Denmark

    T A Kruse

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  1. B Degn
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Correspondence to H Ewald.

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Degn, B., Lundorf, M., Wang, A. et al. Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands. Mol Psychiatry 6, 450–455 (2001). https://doi.org/10.1038/sj.mp.4000882

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