Molecular Psychiatry

FIGURE 3

FROM:

The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior

T Arentsen, Y Qian, S Gkotzis, T Femenia, T Wang, K Udekwu, H Forssberg and R Diaz Heijtz

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Figure 3.

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Manipulation of the gut microbiota alters the brain-specific expression of peptidoglycan-sensing molecules early in life. Gene expression levels of Pglyrp1 (a), Pglyrp2 (b), Pglyrp3 (c), Pglyrp4 (d), Nod1 (e), Nod2 (f), Tlr2 (g) and PepT1 (h) in the striatum of three-day-old germ-free (GF) and perinatal antibiotic-treated male and female mice. All data (ah) are presented as means (±s.e.m.). Significant differences between GF (n=6 for both males and females) and specific pathogen free (SPF; n=5 for both males and females) mice and between perinatal antibiotic-treated (n=5 for males, and n=6 for females) and control (n=5 for males, and n=6 for females) mice are indicated as *P<0.05, **P<0.01 and ***P<0.001.

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