Molecular Psychiatry



The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism

A Di Martino, C-G Yan, Q Li, E Denio, F X Castellanos, K Alaerts, J S Anderson, M Assaf, S Y Bookheimer, M Dapretto, B Deen, S Delmonte, I Dinstein, B Ertl-Wagner, D A Fair, L Gallagher, D P Kennedy, C L Keown, C Keysers, J E Lainhart, C Lord, B Luna, V Menon, N J Minshew, C S Monk, S Mueller, R-A Müller, M B Nebel, J T Nigg, K O'Hearn, K A Pelphrey, S J Peltier, J D Rudie, S Sunaert, M Thioux, J M Tyszka, L Q Uddin, J S Verhoeven, N Wenderoth, J L Wiggins, S H Mostofsky and M P Milham


Figure 2.

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Whole-brain intrinsic functional connectivity analyses. (a) Significant group differences (that is, autism spectrum disorders (ASDs) vs typical controls (TCs)) for intrinsic functional connectivity between each of the 112 parcellation units (56 per hemisphere) included in the structural Harvard–Oxford Atlas. Parcellations are represented with their center of mass overlaid as spheres on glass brains. The upper panel shows the intrinsic functional connections (blue lines) that were significantly weaker in ASD vs TC. The lower panel shows the intrinsic functional connections that were significantly stronger in ASD relative to TC (red lines). Each Harvard–Oxford Atlas unit is colored based on its membership in the six functional divisions as per Mesulam et al.44 (yellow=primary sensorimotor (SM); green=unimodal association; blue=heteromodal association; orange=paralimbic; red=limbic; pink=subcortical). Interhemispheric intrinsic functional connectivity is noted on dorsal and coronal views. Glass brains (left lateral, dorsal and coronal views, shown from left to right) are generated using BrainNet Viewer ( Displayed results are corrected for multiple comparisons using false discovery rate at P<0.05. (b) The table summarizes the absolute number and percentage of node-to-node intrinsic functional connectivity surviving statistical threshold for group comparisons within and between functional divisions. Gray cells represent the absence of significant intrinsic functional connectivity, blue cells represent ASD-related hypoconnectivity (Hypo: ASD<TC), while red cells represent hyperconnectivity (Hyper: ASD>TC). Blue and red shadings decrease proportionally from the highest percentage (37%) to the lowest (~0%). See Supplementary Tables 4–6 for results based on lobar and hemispheric divisions, as well as for those based on the Crad-200 functional parcellation and Supplementary Information for further discussion on the approach.

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