Molecular Psychiatry

TABLE 2

FROM:

Predicting the diagnosis of autism spectrum disorder using gene pathway analysis

E Skafidas, R Testa, D Zantomio, G Chana, I P Everall and C Pantelis

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Table 2. List of 15 most contributory (Table 2a) and 15 most protective (Table 2b) SNPs for ASD diagnosis in the CEU Cohort

SNPWeight lower (0.95)WeightWeight higher (0.95)deltaGene numberGene symbol
(a) Risk SNPs and their weightings
rs9681221.54651.55551.56450.009027345KCNMB4
rs8766190.94761.20921.47080.26162775GNAO1
rs110207720.85530.86410.87290.00882915GRM5
rs92886850.58560.59980.61400.01423635INPP5D
rs101931280.58360.59460.60560.01103635INPP5D
rs78427980.52980.53860.54740.0088114ADCY8
rs37735400.51250.52080.52910.008355799CACNA2D3
rs18181060.50020.51610.53200.015980310PDGFD
rs23840610.41950.43060.44170.0111109ADCY3
rs125829710.39830.42950.46070.03125288PIK3C2G
rs104095410.40670.41890.43110.0122773CACNA1A
rs23004970.37820.38890.39960.0107801CALM1
rs75624450.37410.38430.39450.01022066ERBB4
rs73139970.33820.35670.37520.01855801PTPRR
rs22391180.33480.35520.37560.0204775CACNA1C
       
(b) Protective SNPs and their weightings
rs17629494−0.5242−0.5070−0.48980.01725592PRKG1
rs4648135−0.5807−0.5260−0.47130.05474790NFKB1
rs17643974−0.5527−0.5424−0.53210.01031488CTBP2
rs1243679−0.5771−0.5674−0.55770.0097341799OR6S1
rs2240228−0.5942−0.5816−0.56900.012626532OR10H3
rs260808−0.5938−0.5836−0.57340.010280310PDGFD
rs4128941−0.6166−0.6082−0.59980.00848313AXIN2
rs769052−0.6321−0.6235−0.61490.00867322UBE2D2
rs984371−0.7273−0.7181−0.70890.0092219437OR5L1
rs4308342−1.0196−0.8938−0.76800.12581633DCK
rs11145506−0.9400−0.9172−0.89440.02289630GNA14
rs905646−0.9700−0.9624−0.95480.00762915GRM5
rs6483362−0.9894−0.9661−0.94280.02332915GRM5
rs12317962−1.4869−1.3200−1.15310.166927345KCNMB4
rs8053370−1.7162−1.6956−1.67500.02062775GNAO1

 Abbreviations: ASD, Autism spectrum disorder; CEU, of Central (Western and Northern) European origin; SNP, single-nucleotide polymorphism.

 Weight indicates the contribution of each SNP to ASD clinical status. ‘Weight lower’ indicates the 0.95 lower error bar of the estimate; ‘Weight higher’ indicates the 0.95 upper error bar for that SNP. Note that some genes have SNPs that contribute to risk for ASD and SNPs that protect against ASD.

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