Molecular Psychiatry

TABLE 1

FROM:

Predicting the diagnosis of autism spectrum disorder using gene pathway analysis

E Skafidas, R Testa, D Zantomio, G Chana, I P Everall and C Pantelis

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Table 1. Statistically significant pathways for the CEU and Han Chinese

KEGG pathwayPathway nameCEU significance (P-values)HAN significance (P-values)
hsa04020Calcium signaling5.0 × 10−75.0 × 10−7
hsa04540Gap junction5.0 × 10−75.0 × 10−7
hsa04730Long-term depression5.0 × 10−75.0 × 10−7
hsa04070Phosphotidylinositol signaling1.5 × 10−65.0 × 10−7
hsa04720Long-term potentiation2.5 × 10−65.0 × 10−7
hsa00230Purine metabolism1.0 × 10−55.0 × 10−7
hsa04010mitogen-activated kinase-like protein5.0 × 10−7
hsa04740Olfactory transduction5.0 × 10−7
hsa04910Insulin signaling pathway1.5 × 10−6
hsa04916Melanogenesis2.0 × 10−6
hsa04310Wnt signaling4.0 × 10−6
hsa04912GnRH signaling4.5 × 10−6
hsa04120Ubiquitin-mediated proteolysis7.0 × 10−6
hsa04080Neuroactive ligand receptor1.2 × 10−55.0 × 10−7
hsa04062Chemokine signaling pathway1.2 × 10−55.0 × 10−7
hsa04060Cytokine–cytokine receptor1.65 × 10−55.0 × 10−7
hsa04114Oocyte meiosis5.0 × 10−7
hsa04360Axon guidance5.0 × 10−7
hsa04510Focal adhesion5.0 × 10−7
hsa04514Cell adhesion molecules5.0 × 10−7
hsa04670Leukocyte transendothelial migration5.0 × 10−7
hsa04144Endocytosis2.0 × 10−6
hsa04742Taste transduction2.0 × 10−6

 Abbreviations: CEU, of Central (Western and Northern) European origin; HAN, of Han Chinese origin; KEGG, Kyoto Encyclopedia of Genes and Genomes ().

 P-values in bold are statistically significant. The pathways highlighted in ‘bold’ denote pathways that have reached statistical significance in both populations.

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