Volume 16 Issue 5, May 2011

Macrophage migration inhibitory factor (MIF) is expressed in neurogenic cells in the rodent dentate gyrus, where it plays a key roles in basal and antidepressant-stimulated adult hippocampal cell proliferation, as well as in memory and anxiety- and depression-like behaviors. The figure shows the colocalization of MIF (in red) with the intermediate filament vimentin (marker for astrocytes and stem/progenitor cells, in green) in the subgranular zone of the hippocampus. For more info on this topic, please refer to the article by Conboy et al on pages 533–547.