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X chromosome and suicide

Molecular Psychiatry volume 16, pages 216–226 (2011)Cite this article

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Abstract

Suicide completion rates are significantly higher in males than females in most societies. Although gender differences in suicide rates have been partially explained by environmental and behavioral factors, it is possible that genetic factors, through differential expression between genders, may also help explain gender moderation of suicide risk. This study investigated X-linked genes in suicide completers using a two-step strategy. We first took advantage of the genetic structure of the French-Canadian population and genotyped 722 unrelated French-Canadian male subjects, of whom 333 were suicide completers and 389 were non-suicide controls, using a panel of 37 microsatellite markers spanning the entire X chromosome. Nine haplotype windows and several individual markers were associated with suicide. Significant results aggregated primarily in two regions, one in the long arm and another in the short arm of chromosome X, limited by markers DXS8051 and DXS8102, and DXS1001 and DXS8106, respectively. The second stage of the study investigated differential brain expression of genes mapping to associated regions in Brodmann areas 8/9, 11, 44 and 46, in an independent sample of suicide completers and controls. Six genes within these regions, Rho GTPase-activating protein 6, adaptor-related protein complex 1 sigma 2 subunit, glycoprotein M6B, ribosomal protein S6 kinase 90 kDa polypeptide 3, spermidine/spermine N(1)-acetyltransferase 1 and THO complex 2, were found to be differentially expressed in suicide completers.

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Acknowledgements

The authors thank Veronique Lebel for technical assistance. This work was supported by the Canadian Institute of Health Research (CIHR) MOPs 79253 and 53321. GT is a Fonds de la recherche en santé du Québec (FRSQ) chercheur boursier. LMF received a scholarship from the Natural Sciences and Engineering Research Council of Canada (NSERC).

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  1. McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada

    L M Fiori, H Zouk, C Himmelman & G Turecki

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Fiori, L., Zouk, H., Himmelman, C. et al. X chromosome and suicide. Mol Psychiatry 16, 216–226 (2011). https://doi.org/10.1038/mp.2009.132

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