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A systemic toxicity index developed to assess peripheral changes in mood episodes

Molecular Psychiatry volume 15, pages 784–786 (2010)Cite this article

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Our group and others have put forward a set of targets related to oxidative stress, neurotrophins and inflammation as key mediators of the cognitive and general health impairment that occur with recurrent mood episodes.1, 2, 3, 4 Here, we report the first en bloc assessment of this set of previously described markers of mood episodes in bipolar disorder. For that, we examined these peripheral biomarkers in different mood states of bipolar disorder and in healthy subjects. Finally, to make the point that these are consequential and potentially ominous changes, we measured the same indicators from patients with sepsis, as a ‘positive’ control group with an extreme and massive peripheral illness. We termed the end result of this analysis as a systemic toxicity index (STI).

A total of 60 patients with bipolar I disorder, 80 healthy subjects and seven patients with sepsis were recruited (see Table 1). Psychiatric diagnoses and the current mood state were confirmed with the Structured Clinical Interview for DSM-IV. Healthy subjects were frequency-matched for age and sex. This group was screened with the non-patient version of the Structured Clinical Interview for DSM-IV to exclude psychiatry morbidity, those who had first-degree relatives with BD, schizophrenia or other psychotic disorders. Seven patients with a clinical diagnosis of sepsis (according to the Consensus Conference of the American College of Chest Physicians and Society of Critical Care Medicine) were recruited from an intensive care unit as a ‘positive’ control group. All participants gave written informed consent before entering the study, which was approved by the local ethics committee.

Table 1 Demographical and clinical characteristics of the study sample
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Authors and Affiliations

  1. Bipolar Disorders Program & INCT Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    F Kapczinski, P V S Magalhaes, M Kauer-Sant'Anna & C S Gama

  2. Laboratório de Fisiopatologia Experimental, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil

    F Dal-Pizzol

  3. Laboratory of Immunopharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil

    A L Teixeira

  4. Departamento de Bioquimica, Centro de Estudos em Estresse Oxidativo, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil

    F Klamt & M A de Bittencourt Pasquali

  5. Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, Brazil

    J Quevedo

  6. Penn State College of Medicine, Chevy Chase, MD, USA

    R Post

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  1. F Kapczinski
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  2. F Dal-Pizzol
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  7. M A de Bittencourt Pasquali
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  9. C S Gama
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  10. R Post
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Correspondence to F Kapczinski.

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Kapczinski, F., Dal-Pizzol, F., Teixeira, A. et al. A systemic toxicity index developed to assess peripheral changes in mood episodes. Mol Psychiatry 15, 784–786 (2010). https://doi.org/10.1038/mp.2009.112

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