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Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families

Molecular Psychiatry volume 13, pages 442–450 (2008)Cite this article

Abstract

We report the results of a 10 cM density genome-wide scan and further fine mapping of three chromosomal candidate regions in 10 Belgian multigenerational families with bipolar (BP) disorder. This two-stage approach revealed significant evidence for linkage on chromosome 10q21.3-10q22.3, showing a maximum multipoint parametric heterogeneity logarithm of odds (HLOD) score of 3.28 and a nonparametric linkage (NPL) score of 4.00. Most of the chromosome 10q evidence was derived from a single, large Ashkenazi Jewish pedigree. Haplotype analysis in this pedigree shows that the patients share a 14-marker haplotype, defining a chromosomal candidate region of 19.2 cM. This region was reported previously as a candidate region for BP disorder in several independent linkage analysis studies and in one large meta-analysis. It was also implicated in a linkage study on schizophrenia (SZ) in Ashkenazi Jewish families. Additionally, we found suggestive evidence for linkage on chromosome 19q13.2-13.4 (HLOD 2.01, NPL 1.09) and chromosome 7q21-q22 (HLOD 1.45, NPL 2.28). Together, these observations suggest that a gene located on chromosome 10q21.3-10q22.3 is underlying the susceptibility both for SZ and for BP disorder in at least the Ashkenazi Jewish population.

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Acknowledgements

We thank the patients and their relatives for their cooperation and participation in this research study. The genome-wide genotyping was performed at Généthon (Evry, France) within the framework of the Scientific Program on ‘Molecular Neurobiology of Mental Illness’ financed by the European Science Foundation. We acknowledge the contribution of the personnel of the VIB Genetic Service Facility (http://www.vibgeneticservicefacility.be/) to the genetic analyses. The Interuniversity Attraction Poles program P5/19 of the Federal Science Policy Office, the Fund for Scientific Research Flanders (FWO), and the Special Research Fund of the University of Antwerp (Belgium) have funded this work. MA has a PhD fellowship of FWO. SC is a Senior Clinical Researcher of the FWO.

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  1. S Claes

    Present address: 5Current address: Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium.,

Authors and Affiliations

  1. Department of Molecular Genetics, Flanders Institute for Biotechnology VIB, Antwerpen, Belgium

    T Venken, M Alaerts, D Goossens, S Sluijs, C Van Broeckhoven, J Del-Favero & S Claes

  2. University of Antwerp, Antwerpen, Belgium

    T Venken, M Alaerts, D Goossens, S Sluijs, C Van Broeckhoven & J Del-Favero

  3. Department of Psychiatry, Erasme Hospital, University of Brussels, Brussels, Belgium

    D Souery & J Mendlewicz

  4. Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, University of Tel Aviv, Tel Aviv, Israel

    R Navon

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Correspondence to J Del-Favero.

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Venken, T., Alaerts, M., Souery, D. et al. Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families. Mol Psychiatry 13, 442–450 (2008). https://doi.org/10.1038/sj.mp.4002039

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