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Evidence of association between bipolar disorder and Citron on chromosome 12q24

Molecular Psychiatry volume 10, pages 807–809 (2005)Cite this article

A Corrigendum to this article was published on 25 May 2006

SIR – Bipolar disorder (BP) has a predominantly genetic etiology that has been supported by twin, adoption, and family studies. Several genome-wide linkage analyses conducted for BP have identified a variety of susceptibility loci, including chromosome 4p16, 12q24, 18p11.2, 18q22, 21q21, 22q11–13, and Xq26.1 Many of these loci overlap with those found in schizophrenia (SZ), suggesting common genetic susceptibility factors for both BP and SZ.

In a Scottish family, a hereditary balanced (1;11)(q42.1;q14.3) chromosomal translocation is segregated with major mental illnesses including BP, recurrent major depression, and SZ.2 The translocation leads to an interference in the open reading frame of the Disrupted-in-Schizophrenia-1 (DISC1) gene that could produce a C-terminal truncated DISC1 protein. In a previous study, we conducted a yeast two-hybrid screening in order to identify possible protein interactors involved with cellular signaling of DISC1.3 Among more than 30 interacting proteins, we selected Citron for further analyses because the gene encoding Citron is located on chromosome 12q24, a frequently reported locus linked with BP.4, 5, 6

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Author notes

  1. T Reich: Deceased

Authors and Affiliations

  1. Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    A Lyons-Warren, J J Chang, R Balkissoon, A Kamiya, R DePaulo, M McInnis & A Sawa

  2. Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA

    M Garant

  3. Indiana University, Indianapolis, IN, USA

    J Nurnberger

  4. US Department of Health and Human Services, NIMH Genetics Initiative Bipolar Consortium, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA

    J Nurnberger, W Scheftner, T Reich, F McMahon, J Kelsoe, E Gershon, W Coryell, W Byerley, W Berrettini, R DePaulo & M McInnis

  5. Rush-Presbyterian Medical Center, Chicago, IL, USA

    W Scheftner

  6. Washington University, St Louis, MO, USA

    T Reich

  7. US Department of Health and Human Services, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA

    F McMahon

  8. University of California, San Diego, CA, USA

    J Kelsoe

  9. San Diego Veterans Affairs Healthcare System, San Diego, CA, USA

    J Kelsoe

  10. University of Chicago, Chicago, USA

    E Gershon

  11. University of Iowa, Iowa City, IO, USA

    W Coryell

  12. University of California San Francisco, San Francisco, CA, USA

    W Byerley

  13. San Francisco VA Medical Center, San Francisco, CA, USA

    W Byerley

  14. University of Pennsylvania, Philadelphia, PA, USA

    W Berrettini

  15. Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA

    M McInnis

  16. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    A Sawa

Authors
  1. A Lyons-Warren
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  2. J J Chang
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  3. R Balkissoon
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  4. A Kamiya
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  5. M Garant
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  6. J Nurnberger
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  7. W Scheftner
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  8. T Reich
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  9. F McMahon
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  10. J Kelsoe
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  11. E Gershon
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  12. W Coryell
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  13. W Byerley
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  14. W Berrettini
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  15. R DePaulo
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  16. M McInnis
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  17. A Sawa
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Corresponding author

Correspondence to A Sawa.

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Lyons-Warren, A., Chang, J., Balkissoon, R. et al. Evidence of association between bipolar disorder and Citron on chromosome 12q24. Mol Psychiatry 10, 807–809 (2005). https://doi.org/10.1038/sj.mp.4001703

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