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MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

Molecular Psychiatry volume 10, pages 147–159 (2005)Cite this article

Abstract

The advance of neuroimaging techniques has resulted in a burgeoning of studies reporting abnormalities in brain structure and function in a number of neuropsychiatric disorders. Measurement of hippocampal volume has developed as a useful tool in the study of neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. From this database, the methodology of all original manual tracing protocols were studied. These protocols differed in a number of important factors for accurate hippocampal volume determination including magnetic field strength, the number of slices assessed and the thickness of slices, hippocampal orientation correction, volumetric correction, software used, inter-rater reliability, and anatomical boundaries of the hippocampus. The findings are discussed in relation to optimizing determination of hippocampal volume.

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Acknowledgements

This work was supported by the Dutch Ministry of Defence, the National Institute of Mental Health R01 MH56120, a Veterans Affairs Career Development Award, and the National Center for Post-traumatic Stress Disorder Grant awarded to Dr Bremner.

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Authors and Affiliations

  1. Department of Military Psychiatry, Central Military Hospital, Utrecht, The Netherlands

    E Geuze & E Vermetten

  2. Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands

    E Geuze & E Vermetten

  3. Departments of Psychiatry and Behavioral Sciences and Radiology, Emory University School of Medicine, Atlanta, GA, USA

    J D Bremner

  4. Center for Positron Emission Tomography, Decatur, GA, USA

    J D Bremner

  5. Atlanta VAMC, Decatur, GA, USA

    J D Bremner

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  1. E Geuze
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  2. E Vermetten
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Correspondence to E Geuze.

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Geuze, E., Vermetten, E. & Bremner, J. MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed. Mol Psychiatry 10, 147–159 (2005). https://doi.org/10.1038/sj.mp.4001580

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  • DOI: https://doi.org/10.1038/sj.mp.4001580

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