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Nature Insight Transcribing the Genome

An organism's genome consists of a complex code that specifies not only the DNA sequence of genes but also how and when they are transcribed. Recent technological advances have broadened our understanding of how genomic DNA is transcribed into RNA and how various DNA sequences regulate gene activity.

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NPG Journals in molecular cell biology		Featured Articles
Nature		What recent ribosome structures have revealed about the mechanism of translation (review)
Nature Structural & Molecular Biology		Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps
Nature		Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
Nature Cell Biology		Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
EMBO Journal		Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK
Nature Cell Biology		FLIP-mediated autophagy regulation in cell death control
Nature Structural & Molecular Biology		Molecular architecture of the Nup84–Nup145C–Sec13 edge element in the nuclear pore complex lattice
Nature Reviews Molecular Cell Biology		Non-muscle myosin II takes centre stage in cell adhesion and migration
Cell Research		Endocytosis of FcαR is clathrin and dynamin dependent, but its cytoplasmic domain is not required
EMBO Reports		Protein quality control—linking the unfolded protein response to disease (meeting report)
Molecular Systems Biology		Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway