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Focus on Protein Folding

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Most proteins need to fold to their correct three-dimensional structure to be functional. Defects in protein folding can lead to aggregation or degradation and are associated with several pathological conditions. The June issue of Nature Structural & Molecular Biology contains a Focus on Protein Folding with Reviews and Perspectives covering the basic concepts and the latest developments in the field.

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NPG Journals in molecular cell biology Featured Articles
Nature A conserved ubiquitination pathway determines longevity in response to diet restriction
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EMBO Journal Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
Cell Death & Differentiation The multiple levels of regulation by p53 ubiquitination
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EMBO Reports TIP150 interacts with and targets MCAK at the microtubule plus ends.
Nature Reviews Molecular Cell Biology Growth, fluctuation and switching at microtubule plus ends
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Nature Structural & Molecular Biology The Hsp82 molecular chaperone promotes a switch between unextendable and extendable telomere states

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