Modern Pathology

FIGURE 4

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Endometrial changes from short-term therapy with CDB-4124, a selective progesterone receptor modulator

Olga B Ioffe, Richard J Zaino and George L Mutter

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Figure 4.

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Progesterone receptor modulator-associated endometrial changes ('PAEC') after 154 days of 25 mg daily CDB-4124. At higher CDB-4124 doses, or longer periods of exposure, cyst formation becomes extensive with depletion of intervening stroma to form thin cyst walls (a). In this example, non-physiologic combinations of epithelial secretory vacuoles (b) and apoptotic change (c) are seen.

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