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Primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma: a clonal T-cell lymphoproliferative disorder with indolent behavior

Karen L Grogg, Sungmi Jung, Lori A Erickson, Rebecca F McClure and Ahmet Dogan

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Table 1. Clinicopathologic features in 15 patients with primary cutaneous CD4-positive small/medium sized pleomorphic T-cell lymphoma

  Age/sex Site (size in cm) Clinical impression Phenotypic aberrancy in CD3, CD4+ T cells by IHC Clonal TCR rearrangements Management Relapse Length of follow-up (months)
 155/MForehead (2.5)Firm nodule times 2 monthsDim/absent CD7PCR/Southern blotRadiation therapyNone11
 257/MBehind ear (1)Nodule PCRExcisionNone9
 374/FEyebrow (1)Rapid growth times 2 weeks PCRExcision/ Radiation therapyNone17
 452/FJawline (1)Wax/wane times 6 weeks; indurated nodule; furuncle PCR/Southern blotNone (spontaneous resolution)None24
 560/FBase of neck (NA)Nodule PCRNANANA
 671/MChin (1)NA PCRNANANA
 768/MScalp (NA)Cyst PCRExcisionNone6
 841/MForehead (1.5)NADim CD2PCRExcisionLocal recurrence at 2 months4
 970/FNose (1.3)Ulcerated nodule PCRNANANA
1014/MUpper arm (NA)CystAbsent CD7PCRRadiation therapyNone10
1160/FForearm (14), backPainful expanding lesion times 1year, similar lesions on trunkAbsent CD2PCR/Southern blot times 2 sitesSystemic chemotherapy, autologous stem cell transplantProgression of multifocal cutaneous disease despite therapy26
1254/MShoulder (1.5)Growth times 1 month; dermatofibroma PCRExcisionNone1
1352/FAxilla (1)Nodule times 1 monthDim CD7PCRRadiation therapyNone9
1441/FUpper arm (2)Wax/wane times 6 months; infected cyst PCR/Southern blotExcisionNone4
1566/FBack (1.5)NA PCRNANANA

 NA, not available.

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