Modern Pathology

FIGURE 2

FROM:

IMP-3 is a novel progression marker in malignant melanoma

Jennifer G Pryor, Patricia A Bourne, Qi Yang, Betsy O Spaulding, Glynis A Scott and Haodong Xu

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Figure 2.

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IMP-3 immunohistochemistry showing (a) weak cytoplasmic expression in the dermal component of a Spitz nevus and (b) strong cytoplasmic expression in metastatic melanoma. Compared to (c) patchy IMP-3 expression in a malignant melanoma with a Breslow depth less than or equal to1 mm, (d) malignant melanoma with a Breslow depth >1 mm expresses IMP-3 in >90% of tumor cells. Note the IMP-3 expression in the hair follicle in part (c) (original magnification times 400: a, b; times 200: c, d).

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