Modern Pathology

FIGURE 1

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Gains of COL1A1-PDGFB genomic copies occur in fibrosarcomatous transformation of dermatofibrosarcoma protuberans

Jared J Abbott, Michele Erickson-Johnson, Xiaoke Wang, Antonio G Nascimento and Andre M Oliveira

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Figure 1.

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Case 7. (a) Excision of a superficial tumor from the back of an 85-year-old male shows a classic dermatofibrosarcoma protuberans; a cellular spindle cell tumor diffusely infiltrating the deep dermis and subcutaneous fat with formation of a storiform architectural pattern (H&E; original magnification times 100). (b) The fibrosarcomatous region from the same tumor shows a 'herringbone' fascicular architecture, increased cellularity, and increased mitotic activity (H&E; original magnification times 100). (c) Fluorescence in situ hybridization of the dermatofibrosarcoma protuberans component of the tumor using a custom designed breakapart probe to the PDGFB locus on chromosome 22q13 shows several tumor cells with 1 red–green signal indicating a normal chromosome 22 and 1–3 extra copies of red signal representing COL1A1-PDGFB fusion gene (arrows) (original magnification, times 1000). (d) Fluorescence in situ hybridization of the fibrosarcomatous component of the tumor using a custom designed breakapart probe to the PDGFB locus on chromosome 22q13 shows several tumor cells with 1 red–green signal indicating a normal chromosome 22 and 3–7 extra copies of red signal representing COL1A1-PDGFB fusion gene (arrow) (original magnification, times 1000).

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