Modern Pathology

FIGURE 1

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Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis

Kenzo Hiroshima, Akira Iyoda, Takashi Shida, Kiyoshi Shibuya, Toshihiko Iizasa, Hirohisa Kishi, Tohru Tanizawa, Takehiko Fujisawa and Yukio Nakatani

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Figure 1.

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(a) Large cell neuroendocrine carcinoma. This tumor has organoid nesting and a rosette arrangement. Tumor cells have abundant eosinophilic cytoplasm, coarsely granular chromatin, and prominent nucleoli. Tumor cells with larger nuclei are observed. Necrosis is present. (b) Small cell carcinoma. Cell size is small. Tumor cells have scant cytoplasm so that the cellularity is high. The nuclei are round or oval. The chromatin of the nucleus is vesicular, and nucleoli are inconspicuous. (c) Small cell carcinoma. Cell size is larger than in (b), but smaller than in (a). Tumor cells are polygonal and have a moderate amount of cytoplasm. Rosette-like structures are present. The chromatin of the nucleus is vesicular, and nucleoli are seen. Necrosis is present.

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