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Fatty acid synthase expression in cutaneous melanocytic neoplasms
Payal Kapur, Dinesh Rakheja, Lonnie C Roy and Mai P Hoang
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Figure 1.
Histology and fatty acid synthase expression in (a, d) conventional nevus, (b, e) Spitz nevus, (c, f) congenital melanocytic nevus, (g, j) Clark level II malignant melanoma, (h, k) Clark level IV malignant melanoma, and (i, l) metastatic melanoma. Normal sebaceous gland demonstrates strong fatty acid synthase positivity (d). Fatty acid synthase expression is stronger in primary and metastatic melanomas (j, k, l) in comparison to conventional (d) and Spitz (e) nevi. Of interest, strong fatty acid synthase expression is noted in both congenital melanocytic nevus (f) and metastatic melanoma (l).
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Figure 2.
Mean and 95% confidence interval of fatty acid synthase score of different tumor types.
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Figure 3.
Mean and 95% confidence interval of fatty acid synthase score of primary melanomas within different Clark levels. P-value is statistically significant (0.001 or < 0.001) for Clark level I:IV, I:V, II:IV, and II:V.
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Figure 4.
Mean and 95% confidence interval of fatty acid synthase score of primary melanomas within different Breslow depth categories. P-value is less than 0.001 for Breslow depth <0.75 mm:>1.50 mm. P-value is 0.013 for Breslow depth <0.75 mm: 0.75–1.50 mm.
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