Modern Pathology

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Fatty acid synthase expression in cutaneous melanocytic neoplasms

Payal Kapur, Dinesh Rakheja, Lonnie C Roy and Mai P Hoang

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Figure 1.

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Histology and fatty acid synthase expression in (a, d) conventional nevus, (b, e) Spitz nevus, (c, f) congenital melanocytic nevus, (g, j) Clark level II malignant melanoma, (h, k) Clark level IV malignant melanoma, and (i, l) metastatic melanoma. Normal sebaceous gland demonstrates strong fatty acid synthase positivity (d). Fatty acid synthase expression is stronger in primary and metastatic melanomas (j, k, l) in comparison to conventional (d) and Spitz (e) nevi. Of interest, strong fatty acid synthase expression is noted in both congenital melanocytic nevus (f) and metastatic melanoma (l).

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