FIGURE 1
FROM:
Malignancy-associated X chromosome allelic losses in foregut endocrine neoplasms: further evidence from lung tumors
Tiziana D'Adda, Lorena Bottarelli, Cinzia Azzoni, Silvia Pizzi, Massimo Bongiovanni, Mauro Papotti, Giuseppe Pelosi, Patrick Maisonneuve, Tommaso Antonetti, Guido Rindi and Cesare Bordi
BACK TO ARTICLEFigure 1.
Representative histologic features of neuroendocrine tumors of the lung: (a) typical carcinoid tumor showing nested and trabecular aggregates of bland-appearing, uniform neoplastic cells, with numerous thin blood vessels but no necrosis nor mitotic figures; (b) atypical carcinoid with small foci of punctate tumor necrosis and/or increased mitotic activity (arrow-heads in the inset); (c) large cell neuroendocrine carcinoma characterized by large tumor cells with prominent nucleoli and coarse chromatin, confluent necrotic areas and peripheral palisading of tumor aggregates (inset); (d) small cell lung carcinoma showing oval to spindle, small tumor cells with hyperchromatic and molding nuclei, high nucleus/cytoplasmic ratio, evenly dispersed chromatin, inconspicuous nucleoli, and extensive geographic necrosis.
