FIGURES AND TABLES

Figure 1.

The patient (Case 1) had innumerable cutaneous tumors characterized by a spindle cell proliferation within the dermis and subcutaneous fat (a). The tumors were composed of a diffuse proliferation of spindle cells with elongate cytoplasm and 'buckled' nuclei admixed with numerous mast cells and were morphologically consistent with neurofibromas. An entrapped nerve is present at the top of the field (b).

Figure 2.

Most of the tumor nodules were small, mural lesions with a homogeneous cut surface (Case 1).

Figure 3.

The tumors were largely composed of plump spindle cells arranged in intersecting fascicles and were histologically similar to sporadic GISTs (Case 2).

Figure 4.

Hyperplastic interstitial cells of Cajal, as demonstrated by a CD117 stain, were present in proximity to the tumors in one case (Case 2).

Figure 5.

All tumors strongly expressed CD117 in a diffuse pattern (Case 2).

Figure 6.

Point mutations in three GISTs from one patient (Case 1).

Table 1 - Antibodies and dilutions utilized in the evaluation of GISTs.

Table 2 - KIT and PDGFRA primer sequences with corresponding annealing temperatures.

Table 3 - Results of immunohistochemical stains performed on multiple GISTs.