Modern Pathology

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Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

Paulette Mhawech, Ana Benz, Christelle Cerato, Vincent Greloz, Mounia Assaly, Julian C Desmond, H Phillip Koeffler, Dimitri Lodygin, Heiko Hermeking, François Herrmann and Juerg Schwaller

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Figure 1.

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14-3-3sigma protein expression in normal and malignant urological and gynecological tissues assessed by immunohistochemistry. (a) Normal prostate tissue stained with 14-3-3sigma showed positivity of the basement membrane and some epithelial cells. (b) Normal bladder stained with 14-3-3sigma showed positive staining of the cytoplasm of urothelial cells. (c) A case of prostatic adenocarcinoma sigma showing strong 14-3-3sigma positivity in the cytoplasm and nuclei of tumor cells. (d) Prostatic adenocarcinoma negative for 14-3-3sigma. (e) A case of endometrial adenocarcinoma showing strong positivity of 14-3-3sigma. The expression by tumor cells was mainly cytoplasmic. (f) Endometrial adenocarcinoma negative for 14-3-3sigma.

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