Modern Pathology

FIGURE 2

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A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor

Karen L Grogg, William R Macon, Paul J Kurtin and Antonio G Nascimento

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Figure 2.

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Strong clusterin staining was highly specific for follicular dendritic cell tumor. (a) The large majority of leiomyosarcomas were negative for clusterin, or as in this case showed at most moderate staining in <50% of the cells. (b) This example of malignant melanoma showed spindled morphology and was negative for clusterin. However, strong clusterin staining was present in cells adjacent to areas of necrosis (upper right). Strong clusterin staining was a consistent observation in areas of necrosis, regardless of the degree of positivity in non-necrotic areas. Therefore, this should not be falsely interpreted as inherent positivity within the neoplasm.

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