FIGURE 1
FROM:
High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype
Amy L Lark, Chad A Livasy, Lynn Dressler, Dominic T Moore, Robert C Millikan, Joseph Geradts, Mary Iacocca, David Cowan, Debbie Little, Rolf J Craven and William Cance
BACK TO ARTICLEFigure 1.
Immunohistochemical analysis of FAK expression in invasive breast cancer. Anti-FAK 4.47 monoclonal antibody (1:250) was used to detect FAK expression with slate gray chromagen. Tissue sections for FAK expression is based on a scoring system that measured intensity (0, none; 1, borderline; 2, weak; 3, moderate; 4, strong), percentage positive cells (0–100), and cellular localization (nucleus, cytoplasm, membrane, or combination). FAK expression was dichotomized as high (3+ or 4+ intensity and 
90% positive cells) or not high. (a) FAK expression in invasive breast cancer demonstrating strong cytoplasmic expression ( 
400 magnification). (b) Weak FAK expression demonstrated by faint cytoplasmic staining within invasive breast cancer cells ( 400 magnification). (c) No FAK expression demonstrated in breast cancer cells ( 400 magnification).
