Modern Pathology

FIGURE 2

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Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma

Albert Y Chu, Leslie A Litzky, Theresa L Pasha, Geza Acs and Paul J Zhang

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Figure 2.

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Malignant mesothelioma, epithelioid subtype. (a) Intermediate-power view showing epithelioid tumor cells arranged in a papillary architecture. (b) High power of D2-40 immunostain illustrating membranous pattern of immunoreactivity with highlighting of cell borders. This case was also positive for calretinin (c) and WT1 (d), and negative for cytokeratin 5/6. Note the distinct difference in staining pattern among D2-40 (membrane), calretinin (cytoplasmic), and WT-1 (nuclear).

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