Modern Pathology

FIGURE 2

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Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseases

Agnes Bánkfalvi, Andreas Ludwig, Bettina de-Hesselle, Horst Buerger, Igor B Buchwalow and Werner Boecker

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Figure 2.

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Differential MIB1 growth fractions of different epithelial phenotypes in normal breast tissues, benign proliferative- and early malignant breast diseases (atypical ductal hyperplasia, ductal carcinoma in situ, lobular carcinoma in situ). Abbreviations: UDH=usual ductal hyperplasia; ADH=atypical ductal hyperplasia; DCIS=ductal carcinoma in situ; ALH=atypical lobular hyperplasia; CLIS=lobular carcinoma in situ; sm-actin=smooth muscle actin. Yellow stars: very few proliferating cells with MIB1+/CK5/14+ phenotypes. Green stars: very few or dispersed proliferating cells with MIB1+/smooth muscle actin+ phenotypes.

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