Modern Pathology

TABLE 1

FROM:

Overexpression of caspase-3 in hepatocellular carcinomas

Rajendra Persad, Chen Liu, Tsung-Teh Wu, Patrick S Houlihan, Stanley R Hamilton, Anna M Diehl and Asif Rashid

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Table 1. Caspase-3 overexpression status in HCCs compared to patient and tumor characteristics

Characteristic Total Caspase-3 Overexpression P-value
  (n=47) Absent (n=20) Present (n=27)  
  # % (#) % (#)  
Age (years)plusminuss.d.61.6plusminus13.464.3plusminus12.659.6plusminus13.8NSa
     
Gender     
 Female1937 (7)63 (12)NS
 Male2846 (13)54 (15) 
     
alpha-fetoprotein     
 <401258 (7)42 (5)0.01b
 >401916 (3)84 (16) 
 Not available1663 (10)37 (6) 
     
Hepatitis     
 Absent2544 (11)56 (14)NS
 Present2241 (9)c 59 (13)d  
     
Cirrhosis     
 Absent2437 (9)63 (15)NS
 Present2348 (11)52 (12) 
     
Tumor stage     
 21637 (6)63 (10)NS
 31747 (8)53 (9) 
 41443 (6)57 (8) 
     
Vital status     
 Alive2045 (9)55 (11)NS
 Dead2741 (11)59 (16) 
     
Follow-up (months)plusminuss.d.29.0plusminus29.135.1plusminus32.424.6plusminus26.0NSe

a NS, not significant.

b alpha-fetoprotein <40 vs >40.

c Hepatitis B viral infection (n=3), hepatitis C viral infection (n=2), alcoholic liver disease (n=4), and hepatitis B viral infection and alcoholic liver disease (n=1).

d Hepatitis B viral infection (n=5), hepatitis C viral infection (n=5), alcoholic liver disease (n=3).

e By Kaplan and Meier method, log-rank statistic.

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