FIGURE 2
FROM:
Anaplastic lymphoma kinase (ALK 1) staining and molecular analysis in inflammatory myofibroblastic tumours of the bladder: a preliminary clinicopathological study of nine cases and review of the literature
Alex Freeman, Nicola Geddes, Philippa Munson, Jean Joseph, Pramila Ramani, Ann Sandison, Cyril Fisher and M Connie Parkinson
BACK TO ARTICLEFigure 2.
(a) FISH studies confirm the presence of ALK gene rearrangement in the cells of an IMFT. There is displacement of the green and orange probes against the centromeric and telomeric portion of the common breakpoint region of the ALK gene onto different chromosomes at one allele (white arrow). This shows that part of the ALK gene is translocated from Chromosome 2p onto Chromosome 5. (b) Cells of a leiomyosarcoma show an intact ALK gene at both alleles, with the green and orange probes adjacent to each other (white arrow). This finding confirms that the centromeric and telomeric portion of the ALK gene are on the same chromosome, excluding the presence of a gene translocation at this point.
