Modern Pathology

FIGURE 4

FROM:

Molecular characterization of uterine clear cell carcinoma

Hee-Jung An, Sanjay Logani, Christina Isacson and Lora H Ellenson

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Figure 4.

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p53 exon 8 sequence analysis. (a) p53 exon 8 sequence analysis (antisense) in case 6 (mixed UCC/USC) demonstrates a frameshift mutation (16 bp deletion and 1 bp insertion) from codon 290 to 295 in both components; case 2 demonstrates wild-type exon 8 sequence for comparison.(b) p53 exon 8 sequence analysis (antisense) in case 10 (mixed UCC/UEC) demonstrates a missense mutation (C to T transition), resulting in arginine (CGC) to cysteine (TGC) substitution in both components.

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