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The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas

Vassil Kaimaktchiev, Luigi Terracciano, Luigi Tornillo, Hanspeter Spichtin, Dimitra Stoios, Marcel Bundi, Veselina Korcheva, Martina Mirlacher, Massimo Loda, Guido Sauter and Christopher L Corless

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Figure 1.

CDX2 staining in tissue microarray sections. (a) A colonic adenoma with strong nuclear staining. (b) Four samples of colorectal adenocarcinoma demonstrating varying degrees of staining. (c) Closer view of staining in a moderately differentiated colonic adenocarcinoma. (d) A poorly differentiated colonic adenocarcinoma with patchy nuclear staining. (e) Ovarian carcinoma, endometrioid variant, with positive nuclear staining.

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Figure 2 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Figure 2.

CDX2 staining in whole tissue sections. (a) Metastatic colonic adenocarcinoma in the lung highlighted by strong nuclear staining and some cytoplasmic staining for CDX2. (b) A section of duodenum showing positive staining of the normal mucosa, but no staining of the underlying ductal adenocarcinoma of the pancreas. (c) Ampullary adenocarcinoma with positive nuclear staining; note that the adjacent small pancreatic ducts showed only slight cytoplasmic staining.

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Table 1 - CDX2 staining of human tumors on tissue microarrays - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Table 1 - CDX2 staining of human tumors on tissue microarrays.

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Table 2 - CDX2 staining vs grade and stage of colorectal adenocarcinomas - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Table 2 - CDX2 staining vs grade and stage of colorectal adenocarcinomas.

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Table 3 - CDX2, CK7 and CK20 staining in distant metastases of colorectal adenocarcinomas - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Table 3 - CDX2, CK7 and CK20 staining in distant metastases of colorectal adenocarcinomas.

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Table 4 - CDX2, CK7 and CK20 staining in adenocarcinomas of the ampulla, pancreas and biliary tree - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Table 4 - CDX2, CK7 and CK20 staining in adenocarcinomas of the ampulla, pancreas and biliary tree.

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