Modern Pathology

FIGURE 2

FROM:

Value of the CD8-CD3 Ratio for the Diagnosis of Mycosis Fungoides

Nicolas Ortonne, Nesimi Buyukbabani, Marie-Hélène Delfau-Larue, Martine Bagot and Janine Wechsler

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FIGURE 2.

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A–B, a mycosis fungoides case classified as suggestive morphologically. A, single CD3+ cell epidermotropism is present and numerous CD3+ lymphocytes are observed in the papillary dermis. B, no epidermal lymphocytes express CD8, and only few dermal CD8+ lymphocytes are seen (dermal CD8-CD3 ratio <50%). C–D, an inflammatory dermatosis simulating mycosis fungoides. C, many CD3+ lymphocytes are present in the epidermis and in the papillary dermis. D, most epidermal lymphocytes express CD8 (CD8-CD3 ratio >75%), and many CD8+ lymphocytes are present in the dermal infiltrate (CD8-CD3 ratio >50%).

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