TABLE 3
FROM:
Adrenocortical Adenoma and Carcinoma: Histopathological and Molecular Comparative Analysis
Alexander Stojadinovic, Murray F Brennan, Axel Hoos, Atilla Omeroglu, Denis H Y Leung, Maria E Dudas, Aviram Nissan, Carlos Cordon-Cardo and Ronald A Ghossein
BACK TO ARTICLETABLE 3. Cell Cycle Regulator Expression in Adrenocortical Adenoma versus Carcinoma
| Molecular Marker (positive percent cutoff) | Adenoma (n = 33) n (%) | ACC (n = 38) n (%) | P |
|---|---|---|---|
| Ki-67 (5%) | <0.001 | ||
| Negative | 33 (100%) | 20 (64.5%) | |
| Positive | 0 (0%) | 11 (35.5%) | |
| p53 (5%) | 0.107 | ||
| Negative | 38 (100%) | 35 (94.6%) | |
| Positive | 0 (0%) | 2 (5.4%) | |
| mdm-2 (50%) | 0.131 | ||
| Negative | 21 (63.6%) | 28 (80%) | |
| Positive | 12 (36.4%) | 7 (20%) | |
| p21 (10%) | 0.006 | ||
| Negative | 21 (63.6%) | 11 (30.6%) | |
| Positive | 12 (36.4%) | 25 (69.4%) | |
| p27 (30%) | 0.009 | ||
| Negative | 10 (31.3%) | 2 (5.6%) | |
| Positive | 22 (68.8%) | 34 (94.4%) | |
| Bcl-2 (10%) | N/A | ||
| Negative | 33 (100%) | 38 (100%) | |
| Positive | 0 (0%) | 0 (0%) | |
| Cyclin D1 (5%) | N/A | ||
| Negative | 33 (100%) | 38 (100%) | |
| Positive | 0 (0%) | 0 (0%) |
Number of patients in subgroup < total number in respective group reflects tissue loss during specimen micro array processing.
