Modern Pathology

FIGURE 1

FROM:

Most Malignant Fibrous Histiocytomas Developed in the Retroperitoneum Are Dedifferentiated Liposarcomas: A Review of 25 Cases Initially Diagnosed as Malignant Fibrous Histiocytoma

Jean-Michel Coindre, Odette Mariani, Frédéric Chibon, Aline Mairal, Nicolas de Saint Aubain Somerhausen, Elizabeth Favre-Guillevin, Nguyen Binh Bui, Eberhard Stoeckle, Isabelle Hostein and Alain Aurias

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FIGURE 1.

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Case 11. Primary tumor: A, the primary tumor, composed of spindle and pleomorphic cells arranged in short fascicles, was diagnosed as an MFH (only 3 blocks were available); B, immunohistochemistry showed a strong positivity for anti-mdm2 on some tumor cells. Local recurrence (58 blocks): a local recurrence showed the typical aspect of a dedifferentiated liposarcoma combining areas of well-differentiated liposarcoma (C) and areas of poorly differentiated sarcoma (D).

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